Chloride (Cl)

Chloride (Cl) 

Test: In vitro test for the quantitative determination of chloride
Submission Criteria:

Specimen: Serum (preferred) or Plasma: Li-heparin (Do not use ammonium heparin)

Minimum Volume: 2 mL

Container: Gold-top tube

Storage and Stability: Unseparated from cells:              2 hours

Separated from cells:                   7 days at 20-25ºC

7 days at 4-8ºC

365 days at -20ºC

Rejection Criteria: Rejection criteria include but are not limited to:

  1. Specimen containing fibrin or clots.
  2. Excessive platelet clumping
  3. Leaking specimens
  4. Substandard mixing or collection
  5. Expired or improperly stored collection tubes
  6. Improperly filled tubes based on collection tube manufacture’s guidelines.
  7. Contaminated specimens (IV fluid, foreign particles, etc.)
  8. Specimens not analyzed within the appropriate time frame.
  9. Samples not shipped at appropriate temperature. Samples without two proper identifiers or samples having identifiers that do not match the electronic or paper lab requisition.
Turnaround Time: 1 day
Clinical Significance: Chloride is the major extracellular anion and serves to regulate the balance of extracellular fluid distribution. Common causes of decreased chloride include reduced dietary intake, prolonged vomiting and reduced renal reabsorption. Increased chloride values are found in dehydration, kidney failure, some forms of acidosis, high dietary or parenteral chloride intake, and salicylate poisoning.
Reference Ranges:
Age Chloride Range
< 1 year Not established
1-17 years 102-112 mmol/L
≥ 18 years 98-107 mmol/L
Method: Ion-Selective Electrode (ISE) makes use of the unique properties of certain membrane materials develop an electrical potential (electromotive force, EMF) for the measurement of ions in solution.

Roche/Hitachi Cobas ISE